Oxidative and glycolytic skeletal muscles deploy protective mechanisms to avoid atrophy under pathophysiological iron overload.

David MartinKévin NayFrançois RobinAmélie RebillardLuz OrfilaBrice MartinPatricia LeroyerPascal GuggenbuhlSuzanne DufresnePhilippe NoirezMartine RopertOlivier LoréalFrédéric Derbré

Published in: Journal of cachexia, sarcopenia and muscle (2022)

Together, these data support that under pathophysiological conditions, skeletal muscle can protect itself from the related deleterious effects of excess iron.

Keyphrases

skeletal muscle
iron deficiency
insulin resistance
electronic health record
big data
machine learning
adipose tissue
drug induced