Vorinostat and isotretinoin with chemotherapy in young children with embryonal brain tumors: A report from the Pediatric Brain Tumor Consortium (PBTC-026).

Sarah E S LearyLindsay KilburnJ Russell GeyerMehmet KocakJie HuangKyle S SmithJennifer HadleyRalph ErmoianTobey J MacDonaldStewart GoldmanPeter PhillipsTina Young PoussaintJames M OlsonDavid W EllisonIra J DunkelMaryam FouladiArzu Onar-ThomasPaul A Northcott

Published in: Neuro-oncology (2022)

It was safe and feasible to incorporate vorinostat and isotretinoin into an intensive chemotherapy regimen. Further study to define efficacy in this high-risk group of patients is warranted.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
locally advanced
peritoneal dialysis
prognostic factors
histone deacetylase
young adults