Integrating Mendelian Randomization with Single-cell Sequencing Data Reveals the Causal Effect and Related Mechanisms of Smoking on Parkinson's Disease.

Xinyue ZhangZhigang ZhuLiuhui ZhuYing GuanZhouhai ZhuBin LiuHui RenXinglong Yang

Published in: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco (2024)

In order to explore the potential etiology and pathogenesis of Parkinson's disease, this study combined Mendelian randomization, transcriptomics and single-cell sequencing analysis to explore the association between exposure factors and Parkinson's disease, observe and confirm the relationship and mechanism between the two from the perspective of genetics, and provide more reliable evidence for causal inference.

Keyphrases

single cell
rna seq
high throughput
risk assessment
big data
data analysis
human health
high throughput sequencing