Mucin 1 as a Molecular Target of a Novel Diisoquinoline Derivative Combined with Anti-MUC1 Antibody in AGS Gastric Cancer Cells.
Agnieszka GornowiczWojciech SzymanowskiKrzysztof BielawskiZbigniew KałużaOlga MichalakAnna BielawskaPublished in: Molecules (Basel, Switzerland) (2021)
Our study proved that the anti-MUC1 antibody sensitizes human gastric cancer cells to the novel diisoquinoline derivative (OM-86II) via induction of apoptosis and autophagy, and inhibition of selected proteins such as mTOR, sICAM1 and MMP-9.