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Mucin 1 as a Molecular Target of a Novel Diisoquinoline Derivative Combined with Anti-MUC1 Antibody in AGS Gastric Cancer Cells.

Agnieszka GornowiczWojciech SzymanowskiKrzysztof BielawskiZbigniew KałużaOlga MichalakAnna Bielawska
Published in: Molecules (Basel, Switzerland) (2021)
Our study proved that the anti-MUC1 antibody sensitizes human gastric cancer cells to the novel diisoquinoline derivative (OM-86II) via induction of apoptosis and autophagy, and inhibition of selected proteins such as mTOR, sICAM1 and MMP-9.
Keyphrases
  • endoplasmic reticulum stress
  • oxidative stress
  • cell death
  • endothelial cells
  • induced apoptosis
  • signaling pathway
  • cell proliferation
  • cell cycle arrest
  • water soluble
  • induced pluripotent stem cells