Mechanistic Characterization of Cancer-associated Fibroblast Depletion via an Antibody-Drug Conjugate Targeting Fibroblast Activation Protein.
Joseph P GallantHallie M HintzGihan S GunaratneMatthew T BrenemanEmma E RecchiaJayden L WestKendahl L OttErika HeningerAbigail E JacksonNatalie Y LuoZachary T RosenkransReinier HernandezShuang G ZhaoJoshua M LangLabros MeimetisDavid KosoffAaron M LeBeauPublished in: Cancer research communications (2024)
The direct elimination of FAP-expressing CAFs disrupts the cross-talk with cancer cells leading to a proinflammatory response and alterations in the immune microenvironment and antitumor immune response.