Pharmacokinetic/pharmacodynamic model-based optimization of temocillin dosing strategies for the treatment of systemic infections.
Wisse Van OsMarkus ZeitlingerAnh Duc PhamGert-Jan WijnantPerrin Ngougni PokemFrançoise Van BambekeJohan G C van HasseltMarkus ZeitlingerPublished in: The Journal of antimicrobial chemotherapy (2024)
Continuous infusions and 6 g daily doses of temocillin kill E. coli more effectively than 4 g daily doses and intermittent infusions, and may increase efficacy in the treatment of systemic infections. However, higher daily doses may be required to suppress resistance development.