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Transition-Metal-Catalyzed Selective Functionalization of C(sp3 )-H Bonds in Natural Products.

Rashad R KarimovJohn F Hartwig
Published in: Angewandte Chemie (International ed. in English) (2018)
Direct functionalization of natural products is important for studying the structure-activity and structure-property relationships of these molecules. Recent advances in the transition-metal-catalyzed functionalization of C(sp3 )-H bonds, the most abundant yet inert bonds in natural products, have allowed natural product derivatives to be created selectively. Strategies to achieve such transformation are reviewed.
Keyphrases
  • transition metal
  • room temperature
  • ionic liquid