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Novel aromatic carboxamide potentially targeting fungal succinate dehydrogenase: Design, synthesis, biological activities, and molecular dynamics simulation studies.

Aigui ZhangJian YangKe TaoTaiping HouHong Jin
Published in: Pest management science (2023)
Novel aromatic carboxamides without containing pyrazol group had the potential as a class of SDHI, and the strategy of replacing the pyrazol group with the other aryl in the "core" moiety might offer an alternative option in discovery of SDHI fungicides. This article is protected by copyright. All rights reserved.
Keyphrases
  • molecular dynamics simulations
  • molecular docking
  • amino acid
  • small molecule
  • high throughput
  • cancer therapy
  • risk assessment
  • human health
  • climate change
  • cell wall