Risk of vaso-occlusive episodes in patients with sickle cell disease exposed to systemic corticosteroids: a comprehensive review.
Christophe Ferreira de MatosThibault ComontMarie-Pierre CastexMargaux LafaurieOndine WalterGuillaume MoulisJérémie DionPierre CougoulPublished in: Expert review of hematology (2022)
High corticosteroid doses, for any indication , induce vaso-occlusive crises, acute chest syndrome, and re-hospitalization in patients with SCD. There is no evidence of any benefits of corticosteroid use in the SCD acute events. Prevention by hydroxyurea and/or red blood cell transfusion or exchange should be discussed when corticosteroid use is indispensable.
Keyphrases
- sickle cell disease
- red blood cell
- liver failure
- end stage renal disease
- respiratory failure
- drug induced
- ejection fraction
- chronic kidney disease
- newly diagnosed
- aortic dissection
- cardiac surgery
- intensive care unit
- patient reported outcomes
- acute kidney injury
- acute respiratory distress syndrome
- endovascular treatment