Identification of Major Histocompatibility Complex Class II Epitopes From Lyme Autoantigen Apolipoprotein B-100 and Borrelia burgdorferi Mcp4 in Murine Lyme Arthritis.
Rebecca DannerLauren M ProchniakMichaela PereckasJoseph R RouseAmanda WahhabLauren G HacknerRobert B LochheadPublished in: The Journal of infectious diseases (2024)
ApoB-100, a human Lyme autoantigen, undergoes marked epitope expansion during LA development. The paucity of immunogenic B burgdorferi epitopes supports previous findings suggesting CD4+ T-cell responses are suppressed in murine LA.