Transcription shapes DNA replication initiation to preserve genome integrity.
Yang LiuChen AiTingting GanJinchun WuYongpeng JiangXuhao LiuRusen LuNing GaoQing LiXiong JiJiazhi HuPublished in: Genome biology (2021)
RNA polymerase II redistributes MCM complexes, but not the ORC, to prevent early DNA replication from initiating within transcribed regions. This RNA polymerase II-driven MCM redistribution spatially separates transcription and early DNA replication events and avoids the transcription-replication initiation collision, thereby providing a critical regulatory mechanism to preserve genome stability.