The large fraction of heterochromatin in Drosophila neurons is bound by both B-type lamin and HP1a.

Alexey V PindyurinArtem A IlyinAnton V IvankinMikhail V TselebrovskyValentina V NenashevaElena A MikhalevaLudo PagieBas van SteenselYuri Y Shevelyov

Published in: Epigenetics & chromatin (2018)

In various differentiated Drosophila cell types, we discovered the existence of peripheral heterochromatin, similar to that observed in mammals. Our findings support the model that peripheral heterochromatin matures enhancing the repression of unwanted genes as cells terminally differentiate.

Keyphrases

induced apoptosis
cell cycle arrest
chemotherapy induced
single cell
spinal cord
cell therapy
genome wide
endoplasmic reticulum stress
signaling pathway
gene expression
spinal cord injury
bone marrow