Macrophage targeted nanocarrier delivery systems in HIV therapeutics.

Tabassum KhanMayuresh Mayuresh PatkarMunira Momin Abdelwahab Omri

Published in: Expert opinion on drug delivery (2020)

The development of fixed dose combination of antiretroviral drugs into macrophage targeted delivery systems should factor in the inherent plasticity and heterogeneity of macrophages that is dependent on their microenvironment. A rational selection of nanocarriers will facilitate selectivity and enhanced efficacy of antiretroviral drugs accompanied by reduced dosing and toxicity. Such macrophage targeted delivery systems would positively impact the therapeutic outcomes in the management of HIV infection.

Keyphrases

hiv infected
antiretroviral therapy
cancer therapy
hiv positive
human immunodeficiency virus
hiv aids
drug delivery
hiv infected patients
adipose tissue
hepatitis c virus
stem cells
small molecule
oxidative stress
type diabetes
insulin resistance
drug induced
drug release