The APOE∗3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis.

Marianne G Pouwer Suvi E Heinonen Margareta Behrendt Anne-Christine AndréassonArianne van KoppenAswin L MenkeElsbet J PietermanAnita M van den HoekJ Wouter JukemaBrendan Leighton Ann-Cathrine Jönsson-Rylander Hans M G Princen

Published in: Journal of diabetes research (2019)

We conclude that the E3L.GK+/- mouse is a promising novel diet-inducible disease model for investigation of the etiology and evaluation of drug treatment on diabetic atherosclerosis.

Keyphrases

type diabetes
cardiovascular disease
wound healing
physical activity
early onset
glycemic control
insulin resistance
weight loss
high fat diet
cognitive decline
metabolic syndrome
adipose tissue
mild cognitive impairment
skeletal muscle
combination therapy