Polymorphisms of the dopamine metabolic and signaling pathways are associated with susceptibility to motor levodopa-induced complications (MLIC) in Parkinson's disease: a systematic review and meta-analysis.
Gita Vita SorayaZulvikar Syambani UlhaqSyifaus ShodryMuhammad A'raaf Sirojan KusumaSarah HerawangsaMaharani Oryza SativaAridin GustafDzakky Avecienna Nur FaridwazdiShinta Wulandari FlorentiaNeila RaisaAndi Kurnia BintangMuhammad AkbarPublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2022)
Strong associations were observed between polymorphisms of genes regulating dopamine metabolism with the occurrence of LID and/or MF. The MAO-B rs1799836 may be potential for use as a general pharmacogenetic marker of MLIC, while the COMT rs4680 and rs4633 may be used as markers of LID in Asian ethnicities.
Keyphrases
- uric acid
- signaling pathway
- risk assessment
- genome wide
- parkinson disease
- risk factors
- epithelial mesenchymal transition
- deep brain stimulation
- gene expression
- drug induced
- pi k akt
- prefrontal cortex
- cell proliferation
- transcription factor
- genome wide identification
- induced apoptosis
- bioinformatics analysis
- stress induced