A 3'-pre-tRNA-derived small RNA tRF-1-Ser regulated by 25(OH)D promotes proliferation and stemness by inhibiting the function of MBNL1 in breast cancer.
Xinyu WanWenjie ShiLingjun MaLexin WangRan ZhengJinzhi HeYe WangXuan LiXiaoming ZhaJue WangLu XuPublished in: Clinical and translational medicine (2024)
In brief, our research revealed a novel anticancer mechanism of 25(OH)D, unveiled the vital function of tRF-1-Ser in BRCA progression, and suggested that tRF-1-Ser could emerge as a new therapeutic target for BRCA.