Transition to severe phenotype in systemic lupus erythematosus initially presenting with non-severe disease: implications for the management of early disease.
Dionysis S NikolopoulosMyrto KostopoulouAntigoni PietaSofia FloudaKaterina ChavatzaAggelos BanosJohn BoletisPelagia KatsimbriDimitrios T BoumpasAntonis FanouriakisPublished in: Lupus science & medicine (2021)
Almost half of patients with initially non-severe disease progress to more severe forms of SLE, especially men and patients with positive anti-double-stranded DNA or neuropsychiatric involvement at onset. These data may have implications for the management of milder forms of lupus.