Glial cell line-derived neurotrophic factor (GDNF) mediates hepatic stellate cell activation via ALK5/Smad signalling.

Le TaoWenting MaLiu WuMingyi XuYanqin YangWei ZhangWenjun ShaHongshan LiJianrong XuRilu FengDongying XueJie ZhangSteven DooleyEkihiro SekiPing LiuCheng Liu

Published in: Gut (2019)

GDNF promotes HSC activation and liver fibrosis through ALK5/Smad signalling. Inhibition of GDNF could be a novel therapeutic strategy to combat liver fibrosis.

Keyphrases

liver fibrosis
epithelial mesenchymal transition
transforming growth factor
advanced non small cell lung cancer
single cell
neuropathic pain
stem cells
signaling pathway
spinal cord