GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition.
Audrys G PauzaPratik C ThakkarTatjana TasicIgor S A FelippePaul BishopMichael Paul GreenwoodKristina Rysevaite-KyguolieneJulia AstJohannes BroichhagenDavid J HodsonHelio C SalgadoDainius H PauzaNina Japundzic-ZigonJulian F R PatonDavid MurphyPublished in: Circulation research (2022)
We show that GLP1 (glucagon-like peptide-1) modulates the peripheral chemoreflex acting on the CB, supporting this organ as a multimodal receptor. Our findings pinpoint CBs as potential targets for ameliorating excessive sympathetic activity using GLP1R agonists in the hypertensive-diabetic condition.