SARS-CoV-2 mRNA vaccines induce greater complement activation and decreased viremia and Nef antibodies in men with HIV-1.
Dylan J TuttlePriscila Mayrelle da Silva CastanhaAmro NasserMaris S WilkinsTamara García GalarzaMounia Alaoui-El-AzherDeirdre E CuffPrabal ChhibbarJishnu DasYijia LiSimon M Barratt-BoyesRobbie B MailliardNicolas Sluis-CremerCharles R RinaldoErnesto T A MarquesPublished in: The Journal of infectious diseases (2023)
MWH respond to SARS-CoV-2 mRNA vaccines with lower antibody titers and with greater activation of complement, while exhibiting a decrease in HIV-1 viremia and anti-Nef antibodies. These results suggest an important role of complement activation mediating protection in MWH.