Acute Disseminated Encephalomyelitis: Current Perspectives.
Renata Barbosa PaoliloKumaran DeivaRinze NeuteboomKevin RostasyMing LimPublished in: Children (Basel, Switzerland) (2020)
Acute disseminated encephalomyelitis (ADEM) is an immune-mediated central nervous system (CNS) disorder, characterized by polyfocal symptoms, encephalopathy and typical magnetic resonance imaging (MRI) findings, that especially affects young children. Advances in understanding CNS neuroimmune disorders as well as the association of myelin oligodendrocyte glycoprotein antibody (MOG-Ab) with both monophasic and recurrent forms of ADEM have led to new insights into its definition, management and outcome. In this review, we aim to provide an update based on current epidemiologic, clinical, radiological and immunopathological aspects and clinical outcome of ADEM.
Keyphrases
- magnetic resonance imaging
- liver failure
- respiratory failure
- contrast enhanced
- drug induced
- blood brain barrier
- aortic dissection
- computed tomography
- hepatitis b virus
- early onset
- diffusion weighted imaging
- white matter
- physical activity
- sleep quality
- cerebrospinal fluid
- acute respiratory distress syndrome
- light emitting