Longer Hydroxyurea Administration Prior to Imatinib Mesylate is Risk Factor for Unsuccessful Major Molecular Response in Chronic-Phase Chronic Myeloid Leukemia: Possibility of P-Glycoprotein Role.
Ikhwan RinaldiAry Harryanto ReksodiputroSri Widia JusmanAlida HarahapRianto SetiabudySeptelia Inawati WanandiKarmel TambunanCatharina SuhartiPublished in: Asian Pacific journal of cancer prevention : APJCP (2019)
Administration of HU for more than 6 months prior to IM was associated with unsuccessful MMR achievement in chronic-phase CML. The study suggested that P-glycoprotein overexpression as the predictor for unsuccessful MMR achievement.