Altered brain energy metabolism related to astrocytes in Alzheimer's disease.

Kosei HirataKiwamu MatsuokaKenji TagaiHironobu EndoHarutsugu TatebeMaiko OnoNaomi KokuboAsaka OyamaHitoshi ShinotohTakahata KeisukeTakayuki ObataMasoumeh DehghaniJamie NearKazunori KawamuraMing-Rong ZhangHitoshi ShimadaTakanori YokotaTakahiko TokudaMakoto HiguchiYuhei Takado

Published in: Annals of neurology (2023)

We found high myo-inositol levels accompanied by increased lactate levels in the PCC in AD, indicating a link between reactive astrocytes and altered brain energy metabolism. Myo-inositol and plasma GFAP may reflect similar astrocytic changes as biomarkers of AD. This article is protected by copyright. All rights reserved.

Keyphrases

resting state
white matter
functional connectivity
cerebral ischemia
cognitive decline
blood brain barrier
subarachnoid hemorrhage