Metformin Ameliorates Lipotoxic β-Cell Dysfunction through a Concentration-Dependent Dual Mechanism of Action.
Hong Il KimJi Seon LeeByung Kook KwakWon Min HwangMin Joo KimYoung Bum KimSung Soo ChungKyong-Soo ParkPublished in: Diabetes & metabolism journal (2019)
This study suggests that the action of metformin on β-cell lipotoxicity was implemented by different molecular pathways depending on its concentration. Metformin at a usual therapeutic dose is supposed to alleviate lipotoxic β-cell dysfunction through inhibition of oxidative stress and ER stress.