Association Between Systemic Inflammation and Individual Symptoms of Depression: A Pooled Analysis of 15 Population-Based Cohort Studies.

Philipp FrankMarkus JokelaG David BattyDorina CadarAndrew SteptoeMika Kivimäki

Published in: The American journal of psychiatry (2021)

These findings suggest symptom-specific rather than generalized effects of systemic inflammation on depression. Future trials exploring anti-inflammatory treatment regimens for depression may benefit from targeting individuals presenting with symptom profiles characterized by distinct inflammation-related physical and cognitive symptoms.

Keyphrases

sleep quality
depressive symptoms
anti inflammatory
oxidative stress
physical activity
mental health
cancer therapy
patient reported
drug delivery
case report
replacement therapy