Association between perihematomal cerebral blood volume and intracerebral hemorrhage expansion: A computed tomography perfusion study.
Morotti AndreaGiorgio BustoAndrea BernardoniCarmine TamborinoEnrico FainardiPublished in: Annals of neurology (2019)
We investigated whether computed tomography (CT) perfusion can identify intracerebral hemorrhage patients at high risk of hematoma growth (HG). A total of 155 subjects underwent CT perfusion on admission. Variables associated with log-transformed absolute HG were explored with multivariable linear regression. Perihematomal cerebral blood volume (CBV) was inversely associated with HG (B = -0.20; p < 0.001), independently from blood pressure, hematoma volume, and other confounders. This association was not dose dependent, and only very low CBV (<1.4 ml/100 g) was significantly associated with HG (B = 0.25; p < 0.001). In conclusion, reduced perihematomal CBV is associated with HG, suggesting a potential role of the perihematomal region in the pathophysiology of hematoma enlargement. ANN NEUROL 2019;85:943-947.
Keyphrases
- computed tomography
- contrast enhanced
- fluorescent probe
- dual energy
- positron emission tomography
- magnetic resonance imaging
- image quality
- aqueous solution
- blood pressure
- brain injury
- subarachnoid hemorrhage
- magnetic resonance
- emergency department
- type diabetes
- metabolic syndrome
- mass spectrometry
- hypertensive patients
- cerebral blood flow
- skeletal muscle
- blood brain barrier