Evaluating the performance of sample preparation methods for ultra-performance liquid chromatography/mass spectrometry based serum metabonomics.

Wan ChanYao ZhaoJiayin Zhang

Published in: Rapid communications in mass spectrometry : RCM (2019)

The performance of sample preparation methods for UPLC/MS-based serum metabonomics was evaluated systematically. Results showed sample preparation by solvent precipitation using methanol provided the best analytical precision and extraction efficiency for UPLC/MS-based serum metabonomics.

Keyphrases

mass spectrometry
liquid chromatography
simultaneous determination
high resolution mass spectrometry
tandem mass spectrometry
high resolution
high performance liquid chromatography
molecularly imprinted
gas chromatography
capillary electrophoresis
multiple sclerosis
ms ms
solid phase extraction
ionic liquid