New link between the RNA polymerase II-CTD and replication stress.
Helga B LandsverkLise E SandquistLilli T E BayRandi G SyljuåsenPublished in: Molecular & cellular oncology (2021)
Conflicts between transcription and replication are a major source of replication stress. Our recent findings show that proper dephosphorylation of Serine 5 in the carboxy-terminal domain (CTD) of DNA-directed RNA polymerase II subunit RPB1 is needed to prevent such conflicts in human cells.