Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer.
Anaís Sánchez-CastilloElien HeylenJudith HounjetKim G SavelkoulsNatasja G LieuwesRianne BiemansLudwig J DuboisKobe ReyndersKasper M RouschopRianne D W VaesKim De KeersmaeckerMaarten LambrechtLizza E L HendriksDirk K M De RuysscherMarc A VooijsKim Rosalie KampenPublished in: British journal of cancer (2023)
Our findings highlight that targeting serine/glycine metabolism using sertraline restricts cancer cell recovery from radiotherapy and provides tumor control through immunomodulation in NSCLC.