Unveiling blood pressure-associated genes in aortic cells through integrative analysis of GWAS and RNA modification-associated variants.
Huan ZhangYuxi ChenPeng XuDan LiuNaqiong WuLaiyuan WangXing-Bo MoPublished in: Chronic diseases and translational medicine (2024)
The present study identified RNAm-SNPs in BP loci and elucidated the associations between the RNAm-SNPs, gene expression, and BP. The identified BP-associated genes in aortic cells were associated with AD.
Keyphrases
- genome wide
- induced apoptosis
- gene expression
- blood pressure
- cell cycle arrest
- dna methylation
- aortic valve
- left ventricular
- copy number
- pulmonary artery
- endoplasmic reticulum stress
- cell death
- signaling pathway
- metabolic syndrome
- coronary artery
- transcription factor
- pulmonary hypertension
- pi k akt
- genome wide analysis