Protective effect of Berberine on reproductive function and spermatogenesis in diabetic rats via inhibition of ROS/JAK2/NFκB pathway.

Jingyu SongXintao GaoZhe Tang Hao LiYajun RuanZhuo LiuTao WangShaogang WangJihong LiuHongyang Jiang

Published in: Andrology (2020)

ROS/JAK2/NFκB pathway is involved in the DM-induced low reproductive function and impaired spermatogenesis. BB can play a protective role in preserving the reproductive function and spermatogenesis in DM by inhibiting ROS/JAK2/NFκB pathway.

Keyphrases

diabetic rats
oxidative stress
signaling pathway
dna damage
lps induced
cell death
pi k akt
reactive oxygen species
nuclear factor
immune response
growth factor
toll like receptor
skeletal muscle
high glucose
adipose tissue
weight loss
recombinant human