Nickel-Mediated Divergent Trifluoromethylation of Chlorinated and Brominated Phenol Derivatives through Chemoselective Cleavage of Ar-O and Ar-Cl(Br) Bonds.

We report herein that nickel-mediated trifluoromethylation of chlorinated and brominated phenol derivatives ClArOTs and BrArOTf gave chloro(bromo)trifluoromethylarenes through the chemoselective cleavage of Ar-O bonds. Furthermore, under similar reaction conditions, the chemoselective trifluoromethylation of Ar-Cl and Ar-Br bonds of ClArOPiv and BrArOTs was achieved to give trifluoromethylated phenol derivatives.