Extracellular Mitochondrial DNA Is Generated by Fibroblasts and Predicts Death in Idiopathic Pulmonary Fibrosis.

Changwan RyuHuanxing SunMridu GulatiJose D Herazo-MayaYonglin ChenAwo Osafo-AddoCaitlin BrandsdorferJulia WinklerChristina BlaulJaden FaunceHongyi PanTony WoolardArgyrios TzouvelekisDanielle E Antin-OzerkisJonathan T PuchalskiMartin SladeAnjelica L GonzalezDaniel F BogenhagenVarvara KirillovCarol Feghali-BostwickKevin GibsonKathleen LindellRaimund I HerzogCharles S Dela CruzWajahat MehalNaftali KaminskiErica L HerzogGlenda Trujillo

Published in: American journal of respiratory and critical care medicine (2017)

These findings demonstrate a previously unrecognized and highly novel connection between metabolic reprogramming, mtDNA, fibroblast activation, and clinical outcomes that provides new insight into IPF.

Keyphrases

idiopathic pulmonary fibrosis
mitochondrial dna
copy number
interstitial lung disease
extracellular matrix
genome wide
dna methylation
wound healing
systemic sclerosis