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The Indigenous South American Tsimane Exhibit Relatively Modest Decrease in Brain Volume With Age Despite High Systemic Inflammation.

Andrei IrimiaNikhil N ChaudhariDavid J RoblesKenneth A RostowskyAlexander S MaherNahian F ChowdhuryMaria CalvilloVan NgoMargaret GatzWendy J MackE Meng LawM Linda SutherlandJames D SutherlandChristopher J RowanL Samuel WannAdel H AllamRandall C ThompsonDavid E MichalikDaniel K CummingsEdmond SeabrightSarah AlamiAngela R GarciaPaul L HooperJonathan StieglitzBenjamin C TrumbleMichael D GurvenGregory S ThomasCaleb E FinchHillard Kaplan
Published in: The journals of gerontology. Series A, Biological sciences and medical sciences (2022)
Brain atrophy is correlated with risk of cognitive impairment, functional decline, and dementia. Despite a high infectious disease burden, Tsimane forager-horticulturists of Bolivia have the lowest prevalence of coronary atherosclerosis of any studied population and present few cardiovascular disease (CVD) risk factors despite a high burden of infections and therefore inflammation. This study (a) examines the statistical association between brain volume (BV) and age for Tsimane and (b) compares this association to that of 3 industrialized populations in the United States and Europe. This cohort-based panel study enrolled 746 participants aged 40-94 (396 males), from whom computed tomography (CT) head scans were acquired. BV and intracranial volume (ICV) were calculated from automatic head CT segmentations. The linear regression coefficient estimate β^T of the Tsimane (T), describing the relationship between age (predictor) and BV (response, as a percentage of ICV), was calculated for the pooled sample (including both sexes) and for each sex. β^T was compared to the corresponding regression coefficient estimate β^R of samples from the industrialized reference (R) countries. For all comparisons, the null hypothesis β T = β R was rejected both for the combined samples of males and females, as well as separately for each sex. Our results indicate that the Tsimane exhibit a significantly slower decrease in BV with age than populations in the United States and Europe. Such reduced rates of BV decrease, together with a subsistence lifestyle and low CVD risk, may protect brain health despite considerable chronic inflammation related to infectious burden.
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