The Beneficial Effect of an Intra-articular Injection of Losartan on Microfracture-Mediated Cartilage Repair Is Dose Dependent.

Catherine A LoganXueqin Gao Hajime UtsunomiyaAlex C ScibettaMika TalwarSudheer K RavuriJoseph J RuzbarskyJustin W ArnerDandan ZhuWalter R LoweMarc J PhilipponJohnny Huard

Published in: The American journal of sports medicine (2021)

An IA injection of losartan at an optimal dosage represents a novel microfracture enhancement therapy and warrants a clinical trial for future clinical applications.

Keyphrases

clinical trial
angiotensin ii
ultrasound guided
phase ii
study protocol
stem cells
extracellular matrix
double blind
cell therapy
replacement therapy