Clinicopathological Characteristics of Inflammatory Myositis Induced by COVID-19 Vaccine (Pfizer-BioNTech BNT162b2): A Case Report.
Ji Hyoun KimJun Hyoung KimChang Gok WooPublished in: Journal of Korean medical science (2022)
As more individuals were coronavirus disease 2019 (COVID-19) vaccinated, unexpected side effects appeared. Herein, we present the case of a 30-year-old man with myopathy in both extremities after the second dose of the Pfizer-BioNTech (BNT162b2) COVID-19 vaccine. Symptoms, swelling and pain, started from the proximal upper and lower extremities and extended to the distal parts. Although he underwent massive hydration, the muscle enzyme level continuously increased. He complained of dysphagia and dysarthria. Microscopically, muscle biopsy showed multifocal or scattered macrophage infiltration and degenerated myofibers. In contrast to general myopathy including inflammatory myositis and rhabdomyolysis, vaccine-induced inflammatory myositis shows a prolonged increase in muscle enzyme levels and multifocal macrophage infiltration with necrosis of the muscle fibers. Symptoms improved with glucocorticoid and immunosuppressive treatment. If vaccinated individuals experience severe and continuous muscle pain and swelling, clinicians should consider vaccine-induced inflammatory myositis, measure the muscle enzyme levels, and perform muscle biopsy for a definite diagnosis.
Keyphrases
- coronavirus disease
- skeletal muscle
- sars cov
- oxidative stress
- chronic pain
- interstitial lung disease
- late onset
- magnetic resonance imaging
- high glucose
- adipose tissue
- neuropathic pain
- pain management
- respiratory syndrome coronavirus
- physical activity
- acute kidney injury
- early onset
- computed tomography
- rheumatoid arthritis
- soft tissue
- duchenne muscular dystrophy