Network analysis reveals strain-dependent response to misfolded tau aggregates.
Dominic J AcriYanwen YouMason D TateBrianne McCordA Daniel SharifySutha JohnHande KarahanByung-Wook KimLuke Child DabinStéphanie PhiltjensH R Sagara WijeratneTyler J McCrayDaniel C SmithStephanie J BisselBruce T LambCristian A Lasagna-ReevesJungsu KimPublished in: bioRxiv : the preprint server for biology (2023)
Seeding of tau predates the phosphorylation and spreading of tau aggregates. Acri and colleagues report transcriptomic responses to tau and elevated tau seeds in wild-derived mice. This paper creates a rich resource by combining genetics, tau biosensor assays, and transcriptomics.