Inhibition of AMPK/PFKFB3 mediated glycolysis synergizes with penfluridol to suppress gallbladder cancer growth.

Jiahao HuJiasheng CaoRen'an JinBin ZhangWin TopatanaSarun JuengpanichShijie LiTian'en ChenZiyi LuXiujun CaiMing-Yu Chen

Published in: Cell communication and signaling : CCS (2022)

By inhibiting AMPK, the anticancer effects of PF on GBCs were amplified. As a result, our investigations shed new light on the possibility of repurposing PF as an anticancer drug for GBC, and AMPK inhibition in combination with PF may represent a novel therapeutic strategy for GBC. Video abstract.

Keyphrases

skeletal muscle
protein kinase
papillary thyroid
signaling pathway
squamous cell carcinoma
young adults
drug induced