Dual Prognostic Classification of Triple-Negative Breast Cancer by DNA Damage Immune Response and Homologous Recombination Deficiency.
Shane R SteckleinWilliam E BarlowLajos PusztaiKirsten TimmsRichard D KennedyGemma E LoganRobert S SeitzSunil S BadveYesim Gökmen-PolarPeggy PorterHannah LindenDebasish TripathyGabriel N HortobagyiAndrew K GodwinAlastair ThompsonDaniel F HayesPriyanka SharmaPublished in: JCO precision oncology (2023)
Our findings propose DDIR/HRD classification as a potentially clinically relevant approach to categorize tumors on the basis of therapeutic vulnerabilities.