T-cell receptor beta variable gene polymorphism predicts immune-related adverse events during checkpoint blockade immunotherapy.

Bettzy StephenJoud HajjarShrutii SardaDzifa Yawa DuoseJeffrey M ConroyCarl MorrisonAnas AlshawaMingxuan XuAbdulrazzak ZarifaSapna Pradyuman PatelYing YuanEvan KwiatkowskiLinghua WangJordi Rodon AhnertSiqing FuFunda Meric-BernstamGeoffrey M LowmanTimothy LooneyAung Naing

Published in: Journal for immunotherapy of cancer (2023)

The data suggest that long-amplicon TCRB repertoire sequencing can potentially identify TRBV haplotype groups that correlate with the risk of severe irAEs. Germline-encoded TRBV polymorphisms may serve as a predictive biomarker of severe irAEs.

Keyphrases

early onset
dna damage
electronic health record
drug induced
cell cycle
single cell
big data
machine learning
high throughput sequencing