White matter hyperintensity, neurofilament light chain, and cognitive decline.

Anisa DhanaCharles DeCarliKlodian DhanaPankaja DesaiRobert S WilsonDenis A EvansKumar B Rajan

Published in: Annals of clinical and translational neurology (2022)

While both biomarkers, WMH and NfL, were similarly associated with the annual rate of cognitive decline, our study suggests that they provide different underlying mechanisms affecting cognition.

Keyphrases

cognitive decline
mild cognitive impairment
white matter
multiple sclerosis
cerebrospinal fluid