Reduced Thalamic Volume and Metabolites in Type 1 Diabetes with Polyneuropathy.

Tine M HansenJens Brøndum FrøkjærDinesh SelvarajahJanusiya A MuthulingamSolomon TesfayeAnne JuhlAsbjørn M DrewesPoul E JakobsenJesper KarmisholtBirgitte BrockChristina Brock

Published in: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association (2021)

In this cohort with type 1 diabetes and severe DSPN, thalamic atrophy was present and associated with reduced NAA/cre, indicating thalamic structural loss and dysfunction. Thalamic atrophy was associated to reduced sensory function involving large fiber neuropathy and sensation to tetanic stimulation that may reflect synaptic transmission. This may ultimately contribute to the current understanding of the pathophysiology behind the perception changes evident in DSPN.

Keyphrases

deep brain stimulation
type diabetes
oxidative stress
ms ms
early onset
insulin resistance
skeletal muscle
drug induced