Novel indole retinoid derivative induces apoptosis and cell cycle arrest and modulates AKT and ERK signalling in HL-60 cells.

A Selen Gurkan-AlpArzu Zeynep KarabayAsli KocErdem Buyukbingol

Published in: Fundamental & clinical pharmacology (2023)

Collectively, our results reveal compound5 which is a novel indole retinoid compound as a potential active agent for the treatment of acute promyelocytic leukemia.

Keyphrases

cell cycle arrest
pi k akt
signaling pathway
cell death
cell proliferation
induced apoptosis
liver failure
acute myeloid leukemia
bone marrow
respiratory failure
genome wide
single cell
drug induced
combination therapy
oxidative stress
replacement therapy
acute respiratory distress syndrome
mechanical ventilation