Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage.
Terese GeraghtyShingo IshiharaAlia M ObeidatNatalie S AdamczykRahel S HunterJun LiLai WangHoomin LeeFrank C KoAnne-Marie MalfaitRachel E MillerPublished in: bioRxiv : the preprint server for biology (2024)
Acute systemic macrophage depletion reduced the levels of pro-inflammatory macrophages in the DRG and alleviated pain-related behaviors in established surgically induced OA in mice of both sexes, without affecting joint damage. Overall, these studies provide insight into immune cell regulation in the DRG during OA.
Keyphrases
- drug induced
- liver failure
- chronic pain
- respiratory failure
- pain management
- oxidative stress
- high fat diet induced
- neuropathic pain
- adipose tissue
- aortic dissection
- high glucose
- diabetic rats
- type diabetes
- spinal cord
- endothelial cells
- extracorporeal membrane oxygenation
- spinal cord injury
- case control
- acute respiratory distress syndrome