Faecal Microbiota Composition Varies between Patients with Breast Cancer and Healthy Women: A Comparative Case-Control Study.
Christine Bobin-DubigeonHuyen Trang LuuSébastien LeuilletSidonie N LavergneThomas CartonFrançoise Le VaconCatherine MichelEl-Hassane NazihJean-Marie BardPublished in: Nutrients (2021)
The intestinal microbiota plays an essential role in many diseases, such as obesity, irritable bowel disease (IBD), and cancer. This study aimed to characterize the faecal microbiota from early-stage breast cancer (BC) patients and healthy controls. Faeces from newly diagnosed breast cancer patients, mainly for an invasive carcinoma of no specific type (HR+ and HER2-), before any therapeutic treatment and healthy controls were collected for metabarcoding analyses. We show that the Shannon index, used as an index of diversity, was statistically lower in the BC group compared to that of controls. This work highlights a reduction of microbial diversity, a relative enrichment in Firmicutes, as well as a depletion in Bacteroidetes in patients diagnosed with early BC compared to those of healthy women. A tendency towards a decreased relative abundance of Odoribacter sp., Butyricimonas sp., and Coprococcus sp. was observed. This preliminary study suggests that breast cancer patients may differ from healthy subjects in their intestinal bacterial composition.
Keyphrases
- newly diagnosed
- end stage renal disease
- early stage
- ejection fraction
- chronic kidney disease
- type diabetes
- peritoneal dialysis
- metabolic syndrome
- prognostic factors
- polycystic ovary syndrome
- squamous cell carcinoma
- pregnant women
- weight loss
- skeletal muscle
- young adults
- papillary thyroid
- wastewater treatment
- smoking cessation