Melittin induces autophagy to alleviate chronic renal failure in 5/6-nephrectomized rats and angiotensin II-induced damage in podocytes.

Yufan Zhang Huaping Xu Hongwei Qiao Ya Zhao Minmin Jiang

Published in: Nutrition research and practice (2024)

Melittin may offer protection against kidney injury, probably by regulating podocyte autophagy. These results provide the theoretical basis for applying melittin in CRF therapy.

Keyphrases

angiotensin ii
high glucose
oxidative stress
cell death
endothelial cells
endoplasmic reticulum stress
angiotensin converting enzyme
vascular smooth muscle cells
diabetic rats
signaling pathway
diabetic nephropathy
drug induced
stem cells
mesenchymal stem cells
bone marrow
cell therapy
smoking cessation