Dual functions of epigallocatechin gallate surface-modified Au nanorods@selenium composites for near-infrared-II light-responsive synergistic antibacterial therapy.
Bingbing WuYuyan ShaoWei ZhaoYunfang ZhengYunsheng WangDongdong SunPublished in: Journal of biomaterials applications (2022)
Diseases caused by bacterial infections pose ever-increasing threats to human health, making it important to explore alternative antibacterial strategies. Herein, epigallocatechin gallate (EGCG) surface-modified Au nanorods@selenium composites (ASE NPs) were developed for synergistic NIR-II light-responsive antibacterial therapy. In vitro antibacterial experiments demonstrated the improved antibacterial effect of ASE NPs against Staphylococcus aureus ( S. aureus ) compared with EGCG alone. In addition, in vivo studies demonstrated that ASE NPs cured skin wound infections and sepsis in mice caused by S. aureus . Au nanorods with excellent photothermal conversion realized synergistic photothermal therapy (PTT) in the NIR-II biowindow with an improved penetration depth at a low power density. More importantly, toxicity analysis showed that the composites had no toxic effects on major organs. Thus, the EGCG surface-modified Au nanorods@selenium composites with an NIR-II light-responsive synergistic activity hold great promise for the effective treatment of drug-resistant bacterial infections.
Keyphrases
- reduced graphene oxide
- cancer therapy
- drug resistant
- gold nanoparticles
- silver nanoparticles
- photodynamic therapy
- human health
- drug delivery
- wound healing
- staphylococcus aureus
- drug release
- risk assessment
- multidrug resistant
- anti inflammatory
- essential oil
- fluorescence imaging
- acinetobacter baumannii
- intensive care unit
- acute kidney injury
- mesenchymal stem cells
- septic shock
- oxidative stress
- visible light
- cell therapy
- skeletal muscle
- escherichia coli
- replacement therapy
- smoking cessation
- big data