Deletion of the microtubule-associated protein 6 (MAP6) results in skeletal muscle dysfunction.
Muriel SébastienBenoit GiannesiniPerrine AubinJulie BrocardMathilde ChivetLaura PietrangeloSimona BoncompagniChristophe BoscJacques BrocardJohn RenduSylvie Gory-FauréAnnie AndrieuxAnne Fourest-LieuvinJulien FauréIsabelle MartyPublished in: Skeletal muscle (2018)
Altogether, our results demonstrate that MAP6 is involved in skeletal muscle function. Its deletion results in alterations in skeletal muscle contraction which contribute to the global deleterious phenotype of the MAP6 KO mice. As MAP6 KO mouse line is a model for schizophrenia, our work points to a possible muscle weakness associated to some forms of schizophrenia.