Cold extremities in migraine: a marker for vascular dysfunction in women.
K M LinstraM J L PerenboomE W van ZwetF C van WelieR FronczekM R TannemaatM J H WermerA MaassenvandenbrinkG M TerwindtPublished in: European journal of neurology (2020)
Women with migraine more often reported cold extremities compared with controls, possibly indicating a sex-specific vascular vulnerability. Female migraineurs with cold extremities had higher attack frequencies, partly resulting from sleep disturbances. Future studies need to demonstrate whether cold extremities in female migraineurs are a predictor for cardiovascular and cerebrovascular events.