De novo assembly of highly polymorphic metagenomic data using in situ generated reference sequences and a novel BLAST-based assembly pipeline.

You-Yu LinChia-Hung HsiehJiun-Hong ChenXuemei LuJia-Horng KaoPei-Jer ChenDing-Shinn ChenHurng-Yi Wang

Published in: BMC bioinformatics (2017)

Both PDR and BBAP independently increased the assembly efficiency and accuracy of highly polymorphic data, and assembly performances were further improved when used together. BBAP also provides nucleotide frequency information. Together, PDR and BBAP provide powerful tools for metagenomic data studies.

Keyphrases

electronic health record
big data
artificial intelligence
deep learning
genetic diversity